ESPEYB16 1. Pituitary and Neuroendocrinology Updates on Kisspeptin (4 abstracts)
1.10. Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus
Brown RSE , Khant Aung Z , Phillipps HR , Barad Z , Lein HJ , Boehm U , Szawka RE & Grattan DR
Centre for Neuroendocrinology and Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand
To read the full abstract: Endocrinology 2019;160:1323–1332.
Elevated prolactin levels suppress pulsatile release of GnRH from the hypothalamus, with a consequent reduction in pulsatile LH secretion from the pituitary. In this paper, the authors showed in mice that kisspeptin neurons located in the arcuate nucleus (ARC) respond to prolactin and conditional knockout of the prolactin receptor specifically in ARC kisspeptin neurons prevented prolactin-induced suppression of LH secretion.
This paper is interesting for several reasons:
• It shows that acute prolactin administration in mice suppresses LH pulse frequency and reduces circulating LH concentrations.
• Using a specific fluorescent marker, it shows that ARC kisspeptin neurons respond to prolactin, whereas periventricular preoptic kisspeptin neurons do not.
• It confirms the functional difference between these two types of kisspeptin neurons. Their innovative Kiss1-cre model knocked down the prolactin receptor only in ARC kisspeptin neurons but not in periventricular preoptic kisspeptin neurons.
In this model, high prolactin levels act via the prolactin receptor on ARC kisspeptin neurons (the GnRH pulse generator) to suppress GnRH pulses. The effect of a chronic increase in prolactin must now be investigated.
Volume 16
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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