ESPEYB16 1. Pituitary and Neuroendocrinology New Mechanisms (4 abstracts)
1.6. Regulation of feeding by somatostatin neurons in the tuberal nucleus
Luo SX , Huang J , Li Q , Mohammad H , Lee CY , Krishna K , Kok AM , Tan YL , Lim JY , Li H , Yeow LY , Sun J , He M , Grandjean J , Sajikumar S , Han W & Fu Y
Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), Singapore fu_yu@sbic.a-star.edu.sg
To read the full abstract: Science 2018;361:76–81.
The tuberal nucleus (TN) is a hypothalamic region which is well described in humans but remains poorly defined in rodents. In this paper, the authors demonstrated by specific and sophisticated techniques the role of somatostatin expressing TN (TNSST) neurons in the control of food intake in mice. Interestingly, their results showed the specific role of TNSTT neurons in food intake as compared to SST neurons located in the arcuate nucleus. Furthermore, the authors showed that the appetite-promoting hormone, ghrelin, induced a robust activation of TNSST neurons in both in-vivo and in hypothalamic slices. They then confirmed that specific activation of those neurons by chemogenetic or optogenetic effectors indeed promoted a dramatic food consumption. TNSST neurons project to regions in the hypothalamus which are known to be involved in the control of feeding such as the paraventicular nucleus (PVN). These TNSST neuron promoted feeding by inhibiting downstream neurons.
Besides its inhibitory action on GH secretion, SST has many extra-pituitary functions. It also influences behaviour, such grooming, locomotor activity and anxiety. The central role of SST in feeding behavior had been suggested for many years by pharmacological approaches. The interest of this work was to confirm the role of central SST in feeding behavior in-vivo but also to describe a physiological function of neurons located in the TN. SST neurons located in other regions of the hypothalamus are also involved in the control of feeding. Although, somatotastin was already known as a regulator of food intake, for example by suppressing insulin secretion, this work adds a new central orexigenic pathway.
Volume 16
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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