ESPEYB16 10. Type 1 Diabetes Mellitus (1) (20 abstracts)
10.16. BMI, mortality, and cardiovascular outcomes in type 1 diabetes: Findings against an obesity paradox
Edqvist J , Rawshani A , Adiels M , Björck L , Lind M , Svensson AM , Gudbjörnsdottir S , Sattar N & Rosengren A
Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
To read the full abstract: Diabetes Care. 2019;42:1297–1304
In normal populations, high BMI is associated with higher mortality and morbidity, in particular from cardiovascular disease (CVD). In contrast, in type 1 diabetes (T1D), low body weight has been associated with increased mortality risks. This study investigated the importance of weight and weight gain/loss in patients with T1D (n=26,125; mean age 33.3 years; 45% women) recorded in the Swedish National Diabetes Registry from 1998 to 2012.
Mean BMI in patients with T1D increased continuously from 24.7 to 25.7 kg/m2 from 1998 to 2012. Over a median follow-up of 10.9 years, there were 1,031 deaths (33.2% from CVD), 1,460 major CVD events, and 580 hospitalizations for HF. Cox regression was used to calculate risk of all-cause mortality, CVD mortality, major CVD events, hospitalizations for heart failure (HF).
After exclusion of smokers, patients with poor metabolic control, and patients with a short follow-up time, there was no increased risk for mortality in those with BMI <25, while BMI >25 was associated with a minor increase in risk of mortality, major CVD, and HF. In women, associations with BMI were largely absent. Weight gain implied an increased risk of mortality and heart failure, while weight loss was not associated with higher risk.
As is well-established for people without diabetes, among patients with T1D the risks of major CVD events and mortality increase with increasing BMI. These associations are more apparent in men than in women. Hence, this large national study found no evidence of an obesity paradox in people with T1D. These data are important for clinical practice, since good weight control should remain an important treatment goal for all people, with and without T1D!
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more