ESPEYB20 5. Puberty Caroline Gernay, Sara Moline, Anne-Simone Parent (1 abstracts)
5. Puberty
Caroline Gernay 1 , Sara Moline 2 & Anne-Simone Parent 1,2
1Department of Pediatrics, University Hospital Liège, Belgium; 2Neuroendocrinology Unit, GIGA-Neurosciences, University of Liège, Belgium.
Introduction: This year, cohort studies have brought new insights regarding prepubertal and pubertal markers of future gonadal function and illustrated further the influence of physical activity on puberty timing. Basic studies have identified new candidate genes for congenital hypogonadotropic hypogonadism such as jagged-1 and NOS1. They also exposed new data illustrating the role of MKRN3 as a factor involved in progressive plastic changes rather than a sudden switch of puberty and GnRH activity. Some of the most fascinating studies this year discovered new roles for GnRH and its regulator nitric oxide in higher functions such as cognition, opening new perspectives for GnRH treatment and new questions regarding GnRH agonist treatment.
Volume 20
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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