ESPEYB20 1. Thyroid Autoimmune Thyroid Disease (2 abstracts)
1.11. Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK
Conrad N , Misra S , Verbakel JY , Verbeke G , Molenberghs G , Taylor PN , Mason J , Sattar N , McMurray JJV , McInnes IB , Khunti K & Cambridge G
Lancet. 2023 Jun 3;401(10391):1878–1890. doi: 10.1016/S0140-6736(23)00457-9. Epub 2023 May 5. PMID: 37156255
Brief summary: Over the last decades changing incidences for autoimmune diseases have been observed. However, no data are available so far on long-term trends, incidence over the whole age spectrum (child, adults, geriatric patients), and incidence of co-occurrence of the different autoimmune diseases. The presented study provides an extensive population-based cohort study performed in the UK.
The authors used electronic health care records of 22 million individuals of all ages and sexes over a twenty-year period (2000–2019), and ethnicities representative for the population in the UK. The main results are the following: First, incidence rate of any autoimmune disease increased significantly. Second, opposite trends were observed for autoimmune thyroid diseases. While Graves’ disease was among the three diseases with highest increase (celiac disease, Sjögren’s syndrome and Graves’ disease), incidence of Hashimoto thyroiditis decreased most significantly (together with pernicious anemia). Finally, a detailed co-occurrence table is presented including all twelve organ specific autoimmune diseases and seven connective tissue diseases. Both Grave’s disease and Hashimoto thyroiditis can occur in the context of all other autoimmune diseases, the most frequent diseases co-occurring with Graves’ disease were Myasthenia gravis, type 1 diabetes, and Addison’s disease, and type 1 diabetes, Addison’s disease and vitiligo for Hashimoto thyroiditis.
This exhaustive population-based cohort study provides important insights on incidence trends, age-specific incidence, and co-occurrence of 19 autoimmune diseases in general and more specifically also for the pediatric population.
Volume 20
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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