ESPEYB20 12. The Year in Science and Medicine Food for Thought (6 abstracts)
12.15. Adult height and health-related quality of life in patients born small for gestational age treated with recombinant growth hormone
Rodrigez JMR , Toda LI , Lopez ID , Munoz JB , Fresno LS , Hernandez EF & de Arriba Munoz A
Sci Rep. 2023 Feb 23;13(1):3135. https://doi.org/10.1038/s41598-023-30281-z
Brief summary: In this cross-sectional study, Health related quality of life (HRQoL) was assessed in 50 adults of 4 Spanish hospitals with a previous diagnosis of small for gestational age (SGA) who had received growth hormone treatment (rhGH) during childhood. Tests revealed lower scores on mental health domains than on domains related to physical health. Remarkably, no correlation was found between HRQoL in adulthood and final height, rhGH treatment and timing of puberty.
How important are physical characteristics, such as height, for wellbeing in children, adolescents and adults? This seems an ever-returning question that can be examined from numerous perspectives and it is likely to be changing over time, according to societal changes, and of course differ between cultures. Therefore, similar study designs can provide mixed results on this topic.
However, the important finding of this study is not that final adult height, achieved by growth hormone treatment in short SGA children, had no influence on HRQoL in adulthood. Instead, it should be noted that ex-SGA individuals (especially with lower catch-up growth) had lower mental health parameters and therefore may have unmet needs for support. The authors therefore advise to include assessments for HRQoL, neuro-cognitive and psychiatric functioning in their transition to adult age, and to address this issue by future prospective studies.
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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