ESPEYB21 11. Obesity and Weight Regulation Adipocyte Dysfunction and Obesity Related Comorbidities (4 abstracts)
11.15. A spatiotemporal proteomic map of human adipogenesis
Klingelhuber F , Frendo-Cumbo S , Omar-Hmeadi M , Massier L , Kakimoto P , Taylor AJ , Couchet M , Ribicic S , Wabitsch M , Messias AC , Iuso A , Müller TD , Rydén M , Mejhert N & Krahmer N
Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.
Natalie.krahmer@helmholtz-munich.de
Nat Metab 2024 6(5):861-79. doi:10.1038/s42255-024-01025-8. https://pubmed.ncbi.nlm.nih.gov/38565923
Brief Summary: This study created a temporally- and spatially-resolved proteomic atlas of human adipogenesis. It highlights cell restructuring and spatial reorganization of metabolic pathways to optimize cells for lipid accumulation and identifies C19orf12 as a differentiation-induced protein that regulates lipid storage in adipocytes.
This study provides a comprehensive and detailed proteomic map that captures the dynamic changes in protein abundance and localization during human adipogenesis. This is particularly important because previous research primarily focused on transcriptomic analyses, which do not fully capture post-transcriptional regulation and protein dynamics. This study identifies several key proteins and metabolic pathways involved in adipogenesis. For example, C19orf12, a protein previously associated with neuronal disorders1, is shown to regulate lipid storage and mitochondrial function in adipocytes. This finding adds a new dimension to our understanding of how lipid storage capacity is regulated at the protein level, which is crucial for addressing metabolic disorders like obesity and diabetes. The spatiotemporal aspect of the proteomic map is a novel angle, which provides insights into the longitudinal regulation of metabolic pathways in adipose tissue. This level of detail helps elucidate how different cellular compartments coordinate during adipocyte differentiation, and offers potential targets for therapeutic intervention in metabolic diseases.
This proteomic atlas is a valuable resource for future studies aiming to explore the functional roles of identified proteins in adipogenesis and metabolic regulation. It may open avenues for investigating how genetic variations and environmental factors influence adipocyte function at the proteomic level.
Reference: 1. Gagliardi M, Annesi G, Lesca G, Broussolle E, Iannello G, Vaiti V et al. C19orf12 gene mutations in patients with neurodegeneration with brain iron accumulation. Park Relat Disord 2015; 21: 813-816.
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