ESPEYB21 12. Type 2 Diabetes, Metabolic Syndrome and Lipids Metabolic Syndrome (3 abstracts)
12.10. A proposed simplified definition of metabolic syndrome in children and adolescents: a global perspective
Zong X , Kelishadi R , Kim HS , Schwandt P , Matsha TE , Mill JG , Caserta CA , Medeiros CCM , Kollias A , Whincup PH , Pacifico L , López-Bermejo A , Zhao M , Zheng M & Xi B
BMC Med. 2024 May 7;22(1):190. doi:10.1186/s12916-024-03406-y.
Brief Summary: The authors propose a simplified definition of pediatric metabolic syndrome (MetS) for children aged 6-17 years. This uses static cut-offs, enabling easier and quicker assessment in clinical practice, and allowing comparison of MetS prevalence across different pediatric populations.
Comment: There is no consensus on the definition of pediatric metabolic syndrome (MetS). Existing pediatric MetS definitions involve age-, sex- or height-specific percentile cut-offs for central obesity and elevated blood pressure. This complicates the quick assessment of MetS risk and cardiometabolic risk factor clustering in clinical practice.
The proposed MetS definitions replace these percentile-based criteria with simplified static cut-offs (using absolute values) standardized across different ethnic populations. The new definition requires at least 3 of the following 5 components:
1. Central obesity: Waist-to-height ratio (WHtR) ≥0.50 for youth from Europe and the USA, and ≥0.46 for those from Asia, Africa, and South America.
2. High blood pressure: Systolic/diastolic blood pressure ≥130/80 mm Hg for adolescents aged 13–17 years, and ≥120/80 mm Hg for children aged 6-12 years
3. High triglycerides: ≥130 mg/dl at age 10–17 years, and ≥100 mg/dl at age 6–9 years
4. Low HDL-C: <40 mg/dl
5. High fasting blood glucose: ≥100 mg/dl
A validation study was done using individual data of 19,426 adolescents (50.8% males) aged 12–17 years, from Africa, Asia, Europe, North America and South Africa. Overall, MetS prevalence by the new simplified definition was 6.2%, roughly midway between that by the existing IDF (4.2%) and NCEP (7.7%) definitions.
As well as simplified definitions of MetS risk for population level monitoring, an ‘action level’ definition with more stringent cut-offs was proposed to guide clinical practice, to identify severely affected youths who require immediate intervention. Since measurements of waist circumference and blood pressure are not easily converted into age- and weight-adjusted percentiles, the use of absolute values seems highly practical.
Volume 21
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more