ESPEYB21 14. The Year in Science and Medicine Risk and Outcome (5 abstracts)
14.12. Discriminatory value of steroid hormones on polycystic ovary syndrome and clustering of hyperandrogenism and metabolic factors
Zheng Wang , Martijn Van Faassen , Henk Groen , Astrid E.P. Cantineau , Anne Van Oers , Anna Van der Veen , James M. Hawley , Brian G. Keevil , Ido P. Kema & Annemieke Hoek
Endocrine Practice 30 (2024) 348e355. doi: 10.1016/j.eprac.2024.01.007
Brief Summary:This study tested the discriminatory role of 11-oxygenated androgens to diagnose PCOS in women with obesity, and with ( n =132) or without ( n =83) PCOS. No discriminatory role was found. Instead, insulin resistance, blood pressure, obesity and androgens were the principal components characterizing obese PCOS, while no major characteristic finding defined obese non-PCOS women.
Numerous studies have addressed the mechanism of disease of PCOS and the inter-relationship between PCOS and obesity, as the prevalence of obesity is highly increased in women with PCOS. Similarly, several studies have shown that the steroid metabolome is (specifically) altered in women with PCOS and/or obesity. However, so far no study found a diagnostic serum steroid signature to discriminate women with and without PCOS. Although 11-oxy steroids contribute to the pool of active androgens and are significantly elevated in women with PCOS, this study shows that they cannot serve as PCOS diagnostic markers.
Once more a study demonstrates the immense complexity and heterogeneity of PCOS. Although recent research has provided new insights into the steroid metabolism and beyond of this common disorder, we are still far from understanding it. Broad ‘omics’ studies on larger cohorts forming subgroups of PCOS with respect to androgen and/or fertility characteristic are ongoing. Preliminary results presented at recent international endocrine meetings are promising. Hopefully, ESPE YB 2025 will report on some important findings.
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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