ESPEYB21 14. The Year in Science and Medicine YES contributions by Dr. Simge Eren (14.17 and 14.18) (2 abstracts)
14.17. A maternal brain hormone that builds bone
Muriel E. Babey , William C. Krause , Kun Chen , Candice B. Herber , Zsofia Torok , Joni Nikkanen , Ruben Rodriguez , Xiao Zhang , Fernanda Castro-Navarro , Yuting Wang , Erika E. Wheeler , Saul Villeda , J. Kent Leach , Nancy E. Lane , Erica L. Scheller , Charles K. F. Chan , Thomas H. Ambrosi & Holly A. Ingraham
Nature | Vol 632 | 8 August 2024. doi: 10.1038/s41586-024-07634-3
Brief Summary:This study shows that brain-derived cellular communication network factor 3 (CCN3) is a potent osteoanabolic hormone to enhance bone formation in lactating female mice. CCN3 is produced by KISS1 neurons in the brain, and operates through a unique signaling pathway that interacts with bone-forming osteoblasts leading to increased bone formation.
During lactation, the increased calcium demand for milk production leads to considerable bone loss. Normally, estrogen helps counterbalance excessive bone resorption by encouraging bone formation, but levels drop significantly during the postpartum period. This study shows that CCN3, secreted by KISS1 neurons in the arcuate nucleus (ARCKISS1), can compensate for this estrogen drop and acts as a powerful factor for building bone in lactating females. The study reveals CCN3 as the humoral factor previously suggested to generate the dense bone phenotype in females that enhances bone mass and affects skeletal stem cells to boost their frequency and potential for bone formation (1). CCN3 stimulates skeletal stem cell activity in both mice and humans, enhances bone remodeling, and speeds up fracture repair in mice of all ages and both sexes. The role of CCN3 in female physiology became evident when a surge in CCN3 expression in ARC KISS1 neurons was detected during lactation. Reducing CCN3 levels in these neurons led to bone loss in lactating mothers and impaired their ability to sustain their offspring when exposed to a low-calcium diet.
Maintaining bone health is essential throughout life, with early development being critical for establishing strong bones. The impact of CCN3 on bone growth is particularly notable during developmental stages, affecting bone density and the overall skeletal structure. While previous research has underscored the importance of hormonal regulation in bone health, the discovery of CCN3 introduces a novel mechanism through which brain-derived signals influence bone formation. It suggests that maternal factors have a direct impact on bone development. Imbalances in CCN3 levels might be linked to bone density disorders like osteoporosis. Thus gaining a deeper understanding of how CCN3 functions could pave the way for new treatment approaches.
Related literature:
1) Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
Reference: 1. Candice B Herber, William C Krause, Liping Wang, James R Bayrer, Alfred Li, Matthew Schmitz, Aaron Fields, Breanna Ford, Zhi Zhang, Michelle S Reid, Daniel K Nomura, Robert A Nissenson, Stephanie M Correa, Holly A Ingraham Nat. Commun. 10, 163 (2019). doi: 10.1038/s41467-018-08046-4.
Volume 21
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more