ESPE Yearbook of Paediatric Endocrinology

Author for Correspondence: Evangelia Charmandari, MD, MSc, PhD, MRCP(UK), CCST(UK) Professor of Pediatric and Adolescent Endocrinology First Department of Pediatrics National and Kapodistrian University of Athens Medical School ‘Aghia Sophia’ Children’s Hospital Thivon and Papadiamantopoulou Street Athens, 11527, Greece Tel/Fax: +30-213-2013 384 Email:evangelia.charmandari@googlemail.com

Preface

For this year’s chapter, we searched the PubMed for articles on ‘adrenal’ or ‘steroidogenesis’ published in English between June 1, 2023 and July 31, 2024. Our search yielded > 7,000 citations. We examined all citations individually and selected the following collection of basic research and clinical articles. Whenever possible, we avoided topics that were discussed in the Yearbook 2023, unless progress in the field has been incremental. Emerging themes for this year’s chapter include: i) Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland; ii) Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells; iii) Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency; iv) High-resolution daily profiles of tissue adrenal steroids by portable automated collection; v) Pediatric Cushing syndrome: a prospective, multisite, observational cohort study; vi) Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert Consensus statement; vii) Phase 3 clinical trial of Crinecerfont in children with Congenital Adrenal Hyperplasia; and viii) The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1.