ESPEYB21 8. Adrenals Important for Clinical Practice (8 abstracts)
8.5. High-resolution daily profiles of tissue adrenal steroids by portable automated collection
Upton TJ , Zavala E , Methlie P , Kämpe O , Tsagarakis S , Øksnes M , Bensing S , Vassiliadi DA , Grytaas MA , Botusan IR , Ueland G , Berinder K , Simunkova K , Balomenaki M , Margaritopoulos D , Henne N , Crossley R , Russell G , Husebye ES & Lightman SL
Sci Transl Med. 2023; 15(701): eadg8464. https://pubmed.ncbi.nlm.nih.gov/37343084/
Brief Summary: This paper describes a novel ambulatory fraction collector that can be used with microdialysis to obtain high resolution steroid profiles over a 24-hour period.
Comment: The natural circadian and ultradian secretion of adrenal hormones makes single timepoint measurements of these hormones uninformative for clinical decision making (1-3). Repeated sampling during the day requires admission into an atypical, and often disruptive, clinical setting, particularly if overnight sampling is attempted. These authors addressed this issue by developing an ambulatory fraction collector that can be used with microdialysis to collect samples continuously throughout the day without interfering with daily activities.
They enrolled 214 healthy individuals to collect 24-hour steroid profiles, using this new ambulatory sampling method for cortisol, cortisone, corticosterone, 18-hydroxycortisol, aldosterone, tetrahydrocortisol, allo-tetrahydrocortisol and dehydroepiandrosterone sulfate. The study provides data on the normal physiology and dynamics of tissue steroids, as well as normal reference values. These can be used further to define changes associated with adrenal disease, alongside a powerful methodology to improve personalized replacement therapy.
References: 1. Oster H, Challet E, Ott V, Arvat E, de Kloet ER, Dijk DJ, Lightman S, Vgontzas A, Van Cauter E. The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids. Endocr Rev. 2017; 38(1): 3-45. 2. Russell G, Lightman S. The human stress response. Nat Rev Endocrinol. 2019; 15(9): 525-534. 3. Horrocks PM, Jones AF, Ratcliffe WA, Holder G, White A, Holder R, Ratcliffe JG, London DR. Patterns of ACTH and cortisol pulsatility over twenty-four hours in normal males and females. Clin Endocrinol (Oxf). 1990; 32(1): 127-34.
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more