ISSN 1662-4009 (online)

ESPE Yearbook of Paediatric Endocrinology (2024) 21 9.0 | DOI: 10.1530/ey.21.9.0

Unit of Endocrinology and Diabetes, Bambino Gesu` Children’s Hospital, IRCCS, Rome, Italy carla.bizzarri@opbg.net


Introduction: Survival rates for childhood cancers have steadily improved over the past decades. These changes have shifted the concerns of parents and patients. While survival was previously the primary concern, late effects of cancer treatment are now becoming a major health issue. With a 5-year survival rate exceeding 85% for all cancers combined in this age group, many young survivors will live long enough to have biological children, but they may have concerns about the potential impact of cancer treatment on their reproductive outcomes. Large epidemiological studies have reported a significant reduction in fertility in both sexes. Recent studies conducted on adult cancer patients have shown that cancer itself can damage germ cells, even before any treatment. Recent data confirm that cancer survivors perceive an increased risk of infertility but often struggle to accurately estimate their specific risk. Infertility risk counseling can help to reduce the discrepancy between perception and actual risk, decrease psychological distress, and properly inform family planning decisions.

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