Comorbidities – short and long-term complications | 0015 | ESPEYB15 | Yearbook of Paediatric Endocrinology 2018 | ESPE Yearbook of Paediatric Endocrinology

ey0015.10-11 | Comorbidities – short and long-term complications | ESPEYB15

10.11 Association between inflammatory markers and progression to kidney dysfunction: examining different assessment windows in patients with T1DM

NL Baker , KJ Hunt , DR Stevens , G Jarai , GD Rosen , RL Klein , G Virella , MF Lopes-Virella , DCCT/EDIC Research Group

To read the full abstract: Diabetes Care. 2018;41:128-135Renal damage and kidney failure are amongst the most detrimental co-morbidities of T1DM. In order to be able to prevent renal disease in the first place and treat progression of diabetic renal disease to kidney failure, the mechanisms that lead from high blood glucose levels to damage of the vascular bed of the glomerulus and to end stage renal...

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ey0015.10-12 | Comorbidities – short and long-term complications | ESPEYB15

10.12 Risk of severe hypoglycemia in T1DM over 30 years of follow-up in the DCCT/EDIC study

RA Gubitosi-Klug , BH Braffett , NH White , RS Sherwin , FJ Service , JM Lachin , WV Tamborlane

To read the full abstract: Diabetes Care. 2017;40:1010-1016Professor Tamberlane and co-workers investigated the rates of severe hypoglycemia in the DCCT/Epidemiology of Diabetes Interventions and Complications (EDIC) cohort after approximately 30 years of follow-up. In earlier studies, high rates of hypoglycemic episodes had been found to be associated with lower HbA1c levels and intensified insulin ...

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ey0015.10-13 | Comorbidities – short and long-term complications | ESPEYB15

10.13 Prevalence of celiac disease in 52,721 youth with T1DM: international comparison across three continents

ME Craig , N Prinz , CT Boyle , FM Campbell , TW Jones , SE Hofer , JH Simmons , N Holman , E Tham , E Fröhlich-Reiterer , S DuBose , H Thornton , B King , DM Maahs , RW Holl , JT Warner

To read the full abstract: Diabetes Care. 2017;40:1034-1040Researchers from The Children’s Hospital at Westmead, Sydney, Australia as well as scientists from institutions from three different continents, America, Europe and Australia have combined their data from large diabetes registries in order to: examine the prevalence of celiac disease (CD) in populations of patients with T1DM; investigat...

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ey0015.10-14 | Comorbidities – short and long-term complications | ESPEYB15

10.14 Diabetic ketoacidosis at diagnosis of T1DM predicts poor long-term glycemic control

LM Duca , B Wang , M Rewers , A Rewers

To read the full abstract: Diabetes Care. 2017;40:1249-1255Children and adolescents who present in ketoacidosis at manifestation of the disease might represent a subgroup of patients that may have less resilience factors in their families, less adherence to medical advice, might be less attentive to medical symptoms and might be less knowledgeable of medical issues. In addition, they may carry biolog...

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ey0015.10-15 | Comorbidities – short and long-term complications | ESPEYB15

10.15 ACE inhibitors and statins in adolescents with T1DM

ML Marcovecchio , ST Chiesa , S Bond , D Daneman , S Dawson , KC Donaghue , TW Jones , FH Mahmud , SM Marshall , HAW Neil , RN Dalton , J Deanfield , DB Dunger , AdDIT Study Group

To read the full abstract: New Engl J Med 2017; 377:1733-1745We are still unable to reach treatment goals in all children and adolescents with T1DM. The usually earliest microvascular complication developed in adolescents and young adults is microalbuminuria. Therefore this trial focused on the prevention of microalbuminuria in high risk adolescents with an albumin-to-creatinine ratio in the uppe...

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ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2018

10 Type 1 Diabetes Mellitus