ESPEYB15 11 Obesity and Weight Regulation Adipose tissue – a main source of miRNAs (2 abstracts)
11.13 Adipose-derived circulating miRNAs regulate gene expression in other tissues
Thomou T , Mori M , Dreyfuss J , Konishi M , Sakaguchi M , Wolfrum C , Nageswara Raa T , Winnay J , Garcia-Martin R , Grinspoon S , Gorden P & Kahn R
Section on Integrative Physiology & Metabolism, Joslin Diabetes Center and Harvard Medical School, Boston, USA
To read the full abstract: Nature 2017, 542, 450–455
Adipose tissue is no longer considered a passive energy store. Instead, it is well established as an important endocrine contributor. Here, the authors comprehensively show that the function of the adipose tissue as an endocrine organ is not limited to classical adipokines, but also includes miRNAs and maybe other non-coding RNAs. This study indicates that the adipose tissue is the main source of circulating miRNAs, not only in mice but also in humans. They dissected the role of the different adipose tissue depots and showed that adipose tissue derived miRNAs operate in an endocrine manner in distant tissues, such as the liver. In summary, the authors show for the first time the importance of adipose tissue on the whole circulating miRNome, and the impact of adipose tissue derived miRNAs on metabolic processes in other tissues.
Volume 15
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more