Mechanisms of the year

ey0015.3-3 | Mechanisms of the year | ESPEYB15

3.3 Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription

A Godbole , S Lyga , MJ Lohse , D Calebiro

To read the full abstract: Nat Commun 2017;8:443G-protein-coupled receptors (GPCRs) are a large family of receptors localized at the cell membrane, detecting specific ligands such as hormones, neurotransmitters, odors, pheromones. Further, GCPRs are the main element for the photoisomerization process, necessary to convert a photon impulse to an electrical signal in photosensitive gan...

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ey0015.3-4 | Mechanisms of the year | ESPEYB15

3.4 Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

GS Hones , H Rakov , J Logan , XH Liao , E Werbenko , AS Pollard , SM Praestholm , MS Siersbaek , E Rijntjes , J Gassen , S Latteyer , K Engels , KH Strucksberg , P Kleinbongard , D Zwanziger , J Rozman , V Gailus-Durner , H Fuchs , M Hrabe de Angelis , L Klein-Hitpass , J Kohrle , DL Armstrong , L Grontved , JHD Bassett , GR Williams , S Refetoff , D Fuhrer , LC Moeller

To read the full abstract: Proc Natl Acad Sci U S A 2017;114:E11323-E11332The mechanism of thyroid hormone (TH) action is classically attributed to thyroid hormone receptor (THR) binding to thyroid hormone responsive elements (TRE) in promotors of target genes, directly controlling gene expression in target tissues. Thus, THRs alpha (TRa) and beta (TRb) function as TH dependent transcription ...

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ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2018

3 Thyroid

3.3 Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription

3.4 Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

BiosciAbstracts