ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Appl Physiol (1985) 2017;123:1101-1109IGF-1 is a major regulator of growth plate chondrocyte proliferation. While knockout studies reveal substantial impact from both systemic as well from locally-derived IGF-1, transport and distribution patterns within the growth plate remain unknown. Theoretical approaches have been developed to understand the distributio...