ESPE Yearbook of Paediatric Endocrinology

In the puberty field, this year brought new evidence regarding the epigenetic control of puberty. Recent studies confirm that the epigenetic switch from transcriptional repression to activation plays a crucial role in the hypothalamic mechanism controlling the timing of mammalian puberty.We can also see that, although sometime difficult to differentiate in term of clinical presentation, constitutional delay of growth and puberty and hypogonadotropic hypo...