ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2019

2. Antenatal and Neonatal Endocrinology

Gestational Diabetes Mellitus: Neonatal and Long-term Consequences

ey0016.2-9 | Gestational Diabetes Mellitus: Neonatal and Long-term Consequences | ESPEYB16

2.9. Diabetes and obesity during pregnancy are associated with oxidative stress genotoxicity in newborns

MF Castilla-Peon , Bravo PG Medina , R Sanchez-Urbina , JM Gallardo-Montoya , LC Soriano-Lopez , Cruz FM Coronel

J Perinat Med. 2019 Apr 24;47(3):347-353. doi: 10.1515/jpm-2018-0201.This study measured 8-hydroxy-deoxyguanosine (8-OH-dG), a marker of DNA oxidative damage, in venous umbilical cord plasma from newborns of mothers with and without a diabetes diagnosis during pregnancy.Adult offspring born to mothers with gestational diabetes mellitus (GDM) have an increased frequency...

ey0016.2-10 | Gestational Diabetes Mellitus: Neonatal and Long-term Consequences | ESPEYB16

2.10. Association of gestational diabetes with maternal disorders of glucose metabolism and childhood adiposity

WL Jr Lowe , DM Scholtens , LP Lowe , A Kuang , M Nodzenski , O Talbot , PM Catalano , B Linder , WJ Brickman , P Clayton , C Deerochanawong , J Hamilton , JL Josefson , M Lashley , JM Lawrence , Y Lebenthal , R Ma , M Maresh , D McCance , WH Tam , DA Sacks , AR Dyer , BE Metzger , Follow-up Study Cooperative Research Group HAPO

JAMA. 2018 Sep 11;320(10):1005–1016. doi: 10.1001/jama.2018.11628.The aims of this study were to assess whether in utero exposure to untreated gestational diabetes (using the IADPSG criteria) is associated with long-term risk of a disorder of glucose metabolism among mothers and greater adiposity among their children at 10 to 14 years post-partum.The Hyperglycem...