ESPE Yearbook of Paediatric Endocrinology

Preface: This selection of articles in the field of growth and growth factors is characterized by a number of papers unravelling novel pathophysiological mechanisms underlying some forms of severe short stature. Growth plate gene variants have been described in a high proportion of children with severe familial short stature and/or born small for gestational age. Besides, some studies have enriched the knowledge of IGF system physiology showing the key role of IGF-1 receptor i...