ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica
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Yearbook of Paediatric Endocrinology 2019

5. Bone, Growth Plate and Mineral Metabolism

Basic Science - Bone

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Basic Science - Growth Plate
Table of contents
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Basic Science - Mineral Metabolism

ey0016.5-16 | Basic Science - Bone | ESPEYB16

5.16. Discovery of a periosteal stem cell mediating intramembranous bone formation

S Debnath , AR Yallowitz , J McCormick , S Lalani , T Zhang , R Xu , N Li , Y Liu , YS Yang , M Eiseman , JH Shim , M Hameed , JH Healey , MP Bostrom , DA Landau , MB Greenblatt

Abstract: Nature. 2018 Oct;562(7725):133–139.In brief: A newly discovered periosteal stem cell pool with features distinct from other skeletal mesenchymal stem cells (MSCs) is present in murine and human bone and reveals a pivotal function in intramembranous ossification, cortical bone architecture and fracture healing in conditional knockout mouse strains.</st...
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ey0016.5-17 | Basic Science - Bone | ESPEYB16

5.17. Coupling of bone resorption and formation by RANKL reverse signalling

Y Ikebuchi , S Aoki , M Honma , M Hayashi , Y Sugamori , M Khan , Y Kariya , G Kato , Y Tabata , JM Penninger , N Udagawa , K Aoki , H Suzuki

Abstract: Nature. 2018 Sep;561(7722):195–200.In brief: This study used various cell-based methods and animal models to investigate the RANK-RANKL signaling pathway in bone homeostasis. The authors show for the first time, that reverse signaling exists from osteoclast to osteoblast and that vesicular RANK, secreted by the osteoclast, relays information to the osteoblast...
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ey0016.5-18 | Basic Science - Bone | ESPEYB16

5.18. Developmental origin, functional maintenance and genetic rescue of osteoclasts

CE Jacome-Galarza , GI Percin , JT Muller , E Mass , T Lazarov , J Eitler , M Rauner , VK Yadav , L Crozet , M Bohm , PL Loyher , G Karsenty , C Waskow , F Geissmann

Abstract: Nature. 2019 Apr;568(7753):541–545.In brief: Murine knockout studies unravel the developmental origin of osteoclasts in embryonic, erythro-myeloid progenitors, acquiring exceptional longevity by constant fusion with monocytes and rejuvenation of cellular nucleii throughout postnatal life.Comment: Osteoclast function is essentia...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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