Basic Science - Growth Plate | 0016 | ESPEYB16 | Yearbook of Paediatric Endocrinology 2019 | ESPE Yearbook of Paediatric Endocrinology

ey0016.5-13 | Basic Science - Growth Plate | ESPEYB16

5.13. Differential aging of growth plate cartilage underlies differences in bone length and thus helps determine skeletal proportions

JC Lui , YH Jee , P Garrison , JR Iben , S Yue , M Ad , Q Nguyen , B Kikani , Y Wakabayashi , J Baron

Abstract: PLoS Biol. 2018 Jul 23;16(7):e2005263.In brief: In this article, Lui et al, make important observations related to the fundamental limits of longitudinal bone growth implicating the growth plate senescence program as a major regulator of bone size.Comment: A persons right and left arms almost always grow to the same length, bu...

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ey0016.5-14 | Basic Science - Growth Plate | ESPEYB16

5.14. A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate

PT Newton , L Li , B Zhou , C Schweingruber , M Hovorakova , M Xie , X Sun , L Sandhow , AV Artemov , E Ivashkin , S Suter , V Dyachuk , M El Shahawy , A Gritli-Linde , T Bouderlique , J Petersen , A Mollbrink , J Lundeberg , G Enikolopov , H Qian , K Fried , M Kasper , E Hedlund , I Adameyko , L Savendahl , AS Chagin

Abstract: Nature. 2019 Mar;567(7747):234238.In brief: In this article, the authors present evidence that the murine epiphyseal growth plate develops a postnatal stem cell niche with monoclonal properties, that are able to self-renew. They thereby challenge the concept of a continous depletion of progenitor cells as a limiting factor for bone growth.<p class="abste...

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ey0016.5-15 | Basic Science - Growth Plate | ESPEYB16

5.15. mir-374-5p, mir-379-5p, and mir-503-5p Regulate Proliferation and Hypertrophic Differentiation of Growth Plate Chondrocytes in Male Rats

YH Jee , J Wang , S Yue , M Jennings , SJ Clokie , O Nilsson , JC Lui , J Baron

Abstract: Endocrinology. 2018 Mar 1;159(3):14691478.In brief: In this article, a combination of microdissection, miroRNA profiling and transfection studies identify 3 microRNAs that are highly expressed in the proliferative zone and appear to be down-stream mediators of PTHrP signaling in the growth plate.Comment: In the growth plate, P...

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ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2019

5. Bone, Growth Plate and Mineral Metabolism