Basic Science

7.1. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

RA Ross , S Leon , JC Madara , D Schafer , C Fergani , CA Maguire , AM Verstegen , E Brengle , D Kong , AE Herbison , UB Kaiser , BB Lowell , VM Navarro

To read the full abstract: Elife. 2018 Jun 15;7. pii: e35960.Using transgenic mice, this team discover a new role for Pituitary adenylate cyclase activating polypeptide (PACAP) in female puberty and reproduction. This neuropeptide relays nutritional state information in the hypothalamus to regulate gonadotropin-releasing hormone release.Metabolic cues play...

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ey0016.7-2 | Basic Science | ESPEYB16

7.2. SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

MJ Vazquez , CA Toro , JM Castellano , F Ruiz-Pino , J Roa , D Beiroa , V Heras , I Velasco , C Dieguez , L Pinilla , F Gaytan , R Nogueiras , MA Bosch , OK Ronnekleiv , A Lomniczi , SR Ojeda , M Tena-Sempere

To read the full abstract: Nat Commun. 2018 Oct 10;9(1):4194.This study identifies Sirtuin 1 (SIRT1), a fuel-sensing deacetylase, as a molecule that restrains female puberty via epigenetic repression of the puberty-activating gene, Kiss1 in rats.The last few years have brought evidence regarding the epigenetic control of the onset of puberty. It is now cle...

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ey0016.7-3 | Basic Science | ESPEYB16

7.3. Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling

J Roa , A Barroso , F Ruiz-Pino , MJ Vazquez , P Seoane-Collazo , N Martinez-Sanchez , D Garcia-Galiano , T Ilhan , R Pineda , S Leon , M Manfredi-Lozano , V Heras , M Poutanen , JM Castellano , F Gaytan , C Dieguez , L Pinilla , M Lopez , M Tena-Sempere

To read the full abstract: Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10758E10767.The authors show for the first time that central AMP-activated protein kinase (AMPK), the major cellular energy sensor, interplays with Kiss1 to control puberty onset.AMPK is an indispensable cellular energy sensor (1). Beside its ability to directly sense ener...

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ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2019

7. Puberty

7.1. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

7.2. SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

7.3. Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling

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