ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica
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Yearbook of Paediatric Endocrinology 2019

7. Puberty

Treatment

Previous section
Clinical Guidance
Table of contents

ey0016.7-15 | Treatment | ESPEYB16

7.15. Letrozole versus testosterone for promotion of endogenous puberty in boys with constitutional delay of growth and puberty: a randomised controlled phase 3 trial

T Varimo , H Huopio , L Kariola , S Tenhola , R Voutilainen , J Toppari , S Toiviainen-Salo , E Hamalainen , MA Pulkkinen , M Laaperi , A Tarkkanen , K Vaaralahti , PJ Miettinen , M Hero , T Raivio

To read the full abstract: Lancet Child Adolesc Health. 2019 Feb;3(2):109–120This randomised, controlled, open-label trial at four paediatric centres in Finland evaluates aromatase inhibition with letrozole to induce puberty in boys with constitutional delay of growth and puberty.Treatment of delayed puberty aims to promote pubertal development ...
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ey0016.7-16 | Treatment | ESPEYB16

7.16. Toward more targeted and cost-effective gonadotropin-releasing hormone analog treatment in girls with central precocious puberty

PB Kaplowitz , PF Backeljauw , DB Allen

To read the full abstract: Horm Res Paediatr. 2018;90(1):1–7.The authors discuss why GnRH analog therapies should not be used in all girls with central precocious puberty (CPP), but only in those cases where the predicted benefits outweigh the risks and high cost of the treatment.Epidemiological studies in Europe and USA show declining average a...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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