Hypopituitarism: Disease Modeling and New Discoveries

ey0017.1-5 | Hypopituitarism: Disease Modeling and New Discoveries | ESPEYB17

1.5. Hypothalamic contribution to pituitary functions is recapitulated in vitro using 3D-cultured human iPS cells

T Kasai , H Suga , Sakakibara , C Ozone , R Matsumoto , M Kano , K Mitsumoto , K Ogawa , Y Kodani , H Nagasaki , N Inoshita , M Sugiyama , T Onoue , T Tsunekawa , Y Ito , H Takagi , D Hagiwara , S Iwama , M Goto , R Banno , R Takahashi , H Arima

To read the full abstract: Cell Rep. 2020 Jan 7;30(1):1824.e5. doi: 10.1016/j.celrep.2019.12.009. PMID: 31914385.The hypothalamic-pituitary axis influences many body organ systems and its dysfunction can be fatal. A proper in vitro model is important for understanding the disease mechanisms affecting pituitary function. Based on their previous anterior pituitary modelli...

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ey0017.1-6 | Hypopituitarism: Disease Modeling and New Discoveries | ESPEYB17

1.6. Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells

R Matsumoto , H Suga , T Aoi , H Bando , H Fukuoka , G Iguchi , S Narumi , T Hasegawa , K Muguruma , W Ogawa , Y Takahashi

To read the full abstract: J Clin Invest. 2020 Feb 3;130(2):641654. doi: 10.1172/JCI127378. PMID: 31845906.Congenital pituitary hypoplasia (CPH) is a multifactorial disorder, in which the pituitary has not developed correctly. The underlying mechanisms are mostly unknown, and studies are limited by the lack of appropriate disease models. This work modelled the effect of a novel OTX2</e...

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ey0017.1-7 | Hypopituitarism: Disease Modeling and New Discoveries | ESPEYB17

1.7. Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators

C Huisman , H Cho , O Brock , SJ Lim , SM Youn , Y Park , S Kim , SK Lee , A Delogu , JW Lee

To read the full abstract: Nat Commun. 2019 Aug 16;10(1):3696. doi: 10.1038/s41467-019-11667-y. PMID: 31420539.The hypothalamic arcuate nucleus (ARC) controls crucial physiological processes, such as growth, reproduction and energy homeostasis. However, it is unknown how ARC neurons gain their unique cellular identities and what are their developmental relationships. Here, the authors i...

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ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2020

1. Pituitary and Neuroendocrinology

1.5. Hypothalamic contribution to pituitary functions is recapitulated in vitro using 3D-cultured human iPS cells

1.6. Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells

1.7. Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators

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