ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica
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Yearbook of Paediatric Endocrinology 2020

11. Obesity and Weight Regulation

Body Weight Regulation and Insulin Sensitivity

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Body Weight and Appetite/Energy Regulation
Table of contents
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Pharmacologic Treatment

ey0017.11-8 | Body Weight Regulation and Insulin Sensitivity | ESPEYB17

11.8. Brain insulin sensitivity is linked to adiposity and body fat distribution

S Kullmann , V Valenta , R Wagner , O Tschritter , J Machann , HU Haring , H Preissl , A Fritsche , M Heni

To read the full abstract: Nat Commun. 2020;11(1):1841. Published 2020 Apr 15. doi: https://pubmed.ncbi.nlm.nih.gov/32296068/This study by Kullmann et al. investigated the impact of brain insulin resistance on medium and long-term changes in body weight and body fat in adults at high risk for T2DM, undergoing a 24-months lifestyle intervention program (n =28 at the 24-mont...
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ey0017.11-9 | Body Weight Regulation and Insulin Sensitivity | ESPEYB17

11.9. Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity

AE O’Mara , JW Johnson , JD Linderman , RJ Brychta , S McGehee , LA Fletcher , YA Fink , D Kapuria , TM Cassimatis , N Kelsey , C Cero , ZA Sater , F Piccinini , AS Baskin , BP Leitner , H Cai , CM Millo , W Dieckmann , M Walter , NB Javitt , Y Rotman , PJ Walter , M Ader , RN Bergman , P Herscovitch , KY Chen , AM Cypess

To read the full abstract: J Clin Invest. 2020;130(5):2209–2219. doi: https://pubmed.ncbi.nlm.nih.gov/31961826/This clinical study addressed the chronic effects of the β3-adrenergic receptor agonist mirabegron on BAT activity, blood parameters, and insulin sensitivity in a small cohort of healthy women (n =14). Participants were treated for 4 weeks orally with mirabegron ...
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ey0017.11-10 | Body Weight Regulation and Insulin Sensitivity | ESPEYB17

11.10. The [beta]3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans

BS Finlin , H Memetimin , B Zhu , AL Confides , HJ Vekaria , RH El Khouli , ZR Johnson , PM Westgate , J Chen , AJ Morris , PG Sullivan , EE Dupont-Versteegden , PA Kern

To read the full abstract: J Clin Invest. 2020;130(5):2319–2331.This clinical study assessed the effect of the β3-adrenergic agonist mirabegron on glucose homeostasis in obese individuals.Chronic activation of β3-receptors in mice leads to the appearance of brown-like (e.g. ‘beige’) adipocytes in white adipose tissue, a process referred to as ...
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ey0017.11-11 | Body Weight Regulation and Insulin Sensitivity | ESPEYB17

11.11. Steroid metabolomic signature of insulin resistance in childhood obesity

AM Gawlik , M Shmoish , MF Hartmann , SA Wudy , Z Hochberg

To read the full abstract: Diabetes Care. 2020;43(2):405–410. doi: https://pubmed.ncbi.nlm.nih.gov/31727688/Here, Gawlik et al. describe the urinary steroid metabolomic profile associated with insulin resistance (IR) as assessed in a cohort of 87 non-syndromic obese children and adolescents.To explore the previously defined novel concept of a disease-spe...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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