ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2020

3. Thyroid

Thyroid cancer

ey0017.3-14 | Thyroid cancer | ESPEYB17

3.14. Preoperative metabolic classification of thyroid nodules using mass spectrometry imaging of fine-needle aspiration biopsies

RJ DeHoog , J Zhang , E Alore , JQ Lin , W Yu , S Woody , C Almendariz , M Lin , AF Engelsman , SB Sidhu , R Tibshirani , J Suliburk , LS Eberlin

To read the full abstract: Proc Natl Acad Sci U S A. 2019;116:21401–21408.This prospective diagnostic study used desorption electrospray ionization mass spectrometry (DESI-MS) to classify thyroid nodules by their metabolic signature, and more precisely their lipid profile. DESI-MS is a technique using charged aerosols of microdroplets which are sprayed onto a surface (e.g. tissue) to desorb and ionize molecules which are then analyzed by MS...