ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Bone Miner Res. 2019;34(12):2171–2182.In brief: The effect of RANKL inhibition on fibrous dysplasia development is explored here using a mouse model of a fibrous dysplasia-like disorder. Anti-mouse RANKL monoclonal antibody treatment prevented the development and growth of lesions. However, after discontinuation of anti-mouse ...

To read the full abstract: J Bone Miner Res. 2019;34(10):1851–1861.In brief: In a pediatric kidney transplant cohort, glucocorticoid treatment was independently associated with FGF23 levels. Using in vivo and in vitro rat model systems, blocking of Fgfr signalling rescued glucocorticoid-induced skeletal manifestations.Commentary</em...

To read the full abstract: J Bone Miner Res. 2020;35(3):596–60.In brief: Antibody treatment against the Wnt antagonizing sclerostin substantially improves FGF23 levels, serum phosphate and mechanical bone properties in a murine model of X-linked hypophosphatemic rickets, suggesting a role of sclerostin in phosphate metabolism.Commentary: Associa...