ESPE Yearbook of Paediatric Endocrinology

Acta Diabetol. 2021 Mar;58(3):341–354. doi: 10.1007/s00592-020-01619-0. PMID: 33216207.The key findings of this multi-centre prospective cohort study were that neonates born to mothers treated for Gestational diabetes mellitus (GDM) (by lifestyle or medication, e.g. insulin or metformin) had high rates of macrosomia but similar adiposity to those born of mothers with normal glucose...

J Clin Endocrinol Metab. 2020 Dec 1;105(12):dgaa633. doi: 10.1210/clinem/dgaa633. PMID: 32898218.In this study, low risk pregnant women had an ‘early’ OGTT at 18-20 weeks of gestation and these results were correlated with the standard OGTT at 24-28 weeks. Pregnant women with Gestational diabetes mellitus (GDM) who had early OGTT still had a higher risk of delivering macrosomic in...

Front Endocrinol (Lausanne). 2020 Nov 27;11:603021. doi: 10.3389/fendo.2020.603021. PMID: 33329403.This and previous studies have shown that Gestational diabetes mellitus (GDM) alone and maternal obesity/overweight are associated with alterations in the newborn gut microbiota. In this study, there were significant alterations in the newborn gut microbiota species at 2 weeks of age.<p...

Cochrane Database Syst Rev. 2021 Apr 19;4:CD009951. doi: 10.1002/14651858.CD009951.pub3. PMID: 33870484.In summary, this review did not find certain evidence to support the use of probiotics to reduce the risk of GDM. Only 2 studies suggested a possible reduction in the risk of GDM with probiotics. More importantly, and of concern, the review found a high degree of certainty that th...

J Endocrinol. 2020 May;245(2):315–326. doi: 10.1530/JOE-20-0012. PMID: 32171178.As it is not possible to study the histology of the pancreas post-partum in humans, this study used a mouse model of mild glucose intolerance to assess the changes in pancreatic islets after post-partum and assess the impact of pro-inflammatory cytokines. Mice with glucose intolerance during pregnancy continue...