ESPE Yearbook of Paediatric Endocrinology

Cell Metabolism 2022;34(5):667-80.e6. doi: 10.1016/j.cmet.2022.03.006Brief Summary: In preclinical models and a phase 1 trial, a powerful new lipid small molecule was shown to act through a mechanism distinct from those of known hypolipidemic agents. Targeting HNF-1α may be a new therapeutic strategy.Comment: Familial hypercholesterolemia (FH) is the most common...

Current atherosclerosis reports 2022;24(4):265-75. doi: 10.1007/s11883-022-01000-2Brief Summary: This review article discusses emerging therapies targeted at specific genes, proteins and enzymes to selectively alter triglyceride (TG) metabolism.Comment: Hypertriglyceridemia is a long-neglected major cardiovascular disease (CVD) risk factor. Recent epidemiological dat...

Reports Medicine 2021;2(11):100446. doi: 10.1016/j.xcrm.2021.100446Brief Summary: This mouse study validated a novel, safe treatment with ANGPTL3 peptide vaccine. It was effective to improve obesity-induced dyslipidemia and fatty liver in mice, and also improved dyslipidemia and atherosclerosis in a mouse model of familial hypercholesterolemia, with no reported toxicity.<p class="abste...

Eur J Prev Cardiol 2022;29(5):758-65. doi: 10.1093/eurjpc/zwab152Brief Summary: This retrospective study identified an association between high maternal cholesterol levels during pregnancy with more severe heart attacks in young adult offspring.Comment: During pregnancy, physiological increases in total cholesterol and triglyceride (TG) levels occur due to increases in i...

J Clin Lipidol. 2021 Sep-Oct;15(5):682-689. PMID: 34593357 doi: 10.1016/j.jacl.2021.09.045Brief summary: This online survey of cardiologists and primary care physicians, conducted by the National Lipid Association, revealed the need to improve awareness, knowledge and treatment of heterozygous familial hypercholesterolemia (HeFH).Comment: HeFH is an autosomal dominan...

BMJ 2021; 375:e067350 doi: 10.1136/bmj-2021-067350Comment: Do not miss this article from the Christmas edition of The BMJ published in 2021.Short Summary: With some ethanol assistance, the generation of 13 final checklist items and a flow diagram-guided structure of the checklist was produced by a single author who had multiple opinions. These guidelines direct...