ESPE Yearbook of Paediatric Endocrinology

Preface: Globally, new incidences of type 2 diabetes (T2DM) in children and adolescents were estimated as 41 600 in 2021. The first report of a cohort of prepubertal children with T2DM confirms increased prevalence of severe obesity and insulin resistance. The spreading of T2DM worldwide and in young children is seriously alarming. Thirteen years, on average, after initial diagnoses of T2DM, incidence rates for hypertension, dyslipidemia, diabetic kidney disease and retinopath...