ESPE Yearbook of Paediatric Endocrinology

Science. 2021 Aug 13;373(6556):808–812 doi: 10.1126/science.abe5017Brief summary: This study compiled a large database of doubly labeled water measurements on a large (N=6421) and diverse (N=29 countries) population aged between 8 days and 95 years to provide the first comprehensive study of total energy expenditure (TEE) and basal metabolic rate (BMR) over the human li...

Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2101671118. doi: 10.1073/pnas.2101671118Brief Summary: This cell model study shows that cholesterol is essential for the transcriptional repressor and cell differentiation activities of brain acid soluble protein 1 (BASP1).Cholesterol biology covers a spectrum of functions spanning from the biosynthesis of Vitamin D, bile a...

Cell Rep. 2022 Jan 25;38(4):110298. doi: 10.1016/j.celrep.2022.110298Brief Summary: This study describes the cryo-EM structure of human ATP Binding Cassette Subfamily G Member 1 (ABCG1) in complex with cholesterol. The authors propose a structural mechanism whereby cholesterol is recruited from cell membranes by sphingomyelin and loaded on nascent HDL particles.ABC...