Obesity

15.1. Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes

JP Frias , MJ Davies , J Rosenstock , FC Perez Manghi , L Fernandez Lando , BK Bergman , B Liu , X Cui , K Brown , SURPASS-2 Investigators

N Engl J Med. 2021;385(6):503-15. doi: 10.1056/NEJMoa2107519.PubMed ID: 34170647Brief summary: this randomized control trial in 1879 adults with type 2 diabetes compared effects of once-weekly Tirzepatide (5, 10 or 15 mg) versus once-weekly Semaglutide (1 mg) on glycemic control. After 40 weeks, all doses of Tirzepatide were superior to Semaglutide on lowering HbA1c.Gluca...

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ey0019.15-2 | Obesity | ESPEYB19

15.2. Postprandial glycaemic dips predict appetite and energy intake in healthy individuals

P Wyatt , SE Berry , G Finlayson , R O'Driscoll , G Hadjigeorgiou , DA Drew , HA Khatib , LH Nguyen , I Linenberg , AT Chan , TD Spector , PW Franks , J Wolf , J Blundell , AM Valdes

Nat Metab. 2021;3(4):523-9. doi: 10.1038/s42255-021-00383-x.PubMed ID: 33846643Brief summary: this study of around 1000 adults administered standard breakfast meals and showed wide variability and continuously monitored glucose levels up to 3 h afterwards. Notably, those individuals with lower glucose levels at 2 to 3 h after meals reported higher levels of appetite and consumed hundreds m...

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ey0019.15-3 | Obesity | ESPEYB19

15.3. Obesity-associated GNAS mutations and the melanocortin pathway

E Mendes de Oliveira , JM Keogh , F Talbot , E Henning , R Ahmed , A Perdikari , R Bounds , N Wasiluk , V Ayinampudi , I Barroso , J Mokrosinski , D Jyothish , S Lim , S Gupta , M Kershaw , C Matei , P Partha , T Randell , A McAulay , LC Wilson , T Cheetham , EC Crowne , P Clayton , IS Farooqi

N Engl J Med. 2021;385(17):1581-92. doi: 10.1056/NEJMoa2103329.PubMed ID: 34614324Brief Summary: The authors performed whole exome sequencing in 2548 children with severe obesity and identified 22 GNAS mutation carriers, almost all of which disrupted melanocortin 4 receptor (MC4R) signaling.The gene GNAS encodes the stimulatory G-protein alpha subunit pr...

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ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2022

15. Editors’ Choice

15.1. Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes

15.2. Postprandial glycaemic dips predict appetite and energy intake in healthy individuals

15.3. Obesity-associated GNAS mutations and the melanocortin pathway

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