ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2023

1. Thyroid

Endocrine Disruptors

ey0020.1-15 | Endocrine Disruptors | ESPEYB20

1.15. Thyroid-on-a-chip: An organoid platform for in vitro assessment of endocrine disruption

DJ Carvalho , AM Kip , M Romitti , M Nazzari , A Tegel , M Stich , C Krause , F Caiment , S Costagliola , L Moroni , S Giselbrecht

Brief summary: Exposure to endocrine disrupting chemicals may have adverse effects on humans. Tissue specific organoids are a helpful model to study organ specific impact of compounds alone or in combination, at different doses and during different stages of tissue development (1). While such organoid models have been developed for different tissues, such models were lacking to study differentiated thyroid follicles and thyroid tissue during development and differentiation.</p...