ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2023

1. Thyroid

Thyroid Development

ey0020.1-4 | Thyroid Development | ESPEYB20

1.4. Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

M Romitti , A Tourneur , B de Faria da Fonseca , G Doumont , P Gillotay , XH Liao , SE Eski , G Van Simaeys , L Chomette , H Lasolle , O Monestier , DF Kasprzyk , V Detours , SP Singh , S Goldman , S Refetoff , S Costagliola

Brief summary: In recent years, generation of human organoids of different tissues from human embryonic stem cells have been realized, e.g. intestine, liver, and lung among others. In contrast, so far all attempts to generate fully mature and functional human thyroid follicular cells from stem cells was not successful. Romitti et al. present for the first time successful generation of transplantable and functional human thyroid organoids derived from human embryonic s...