ESPE Yearbook of Paediatric Endocrinology

Introduction: This year, cohort studies have brought new insights regarding prepubertal and pubertal markers of future gonadal function and illustrated further the influence of physical activity on puberty timing. Basic studies have identified new candidate genes for congenital hypogonadotropic hypogonadism such as jagged-1 and NOS1. They also exposed new data illustrating the role of MKRN3 as a factor involved in progressive plastic changes rather than a sudden switch of pube...