ESPE Yearbook of Paediatric Endocrinology

Brief summary: This longitudinal study aimed to determine if hyperinsulinemia and postprandial glucose levels could predict obesity progression in n=591 children and adolescents with obesity. The authors found no association between hyperinsulinemia, insulin secretion, low postprandial glucose levels, and an increase in obesity over a 2–4-year period.According to the carbohydrate-insulin model (1), diets with a high glycemic load (GL) promote weight...

Brief summary: Giannini et al. report a timely study on the impact of COVID-19 restrictions on glucose metabolism in children and adolescents with obesity and overweight. They compared data from 741 children over a 13-year period, before and during the COVID-19 pandemic. They found that children in the COVID-19 restriction group did not have significantly increased values of Body Mass Index (BMI), but they did exhibit higher values of Waist Circumference (WC), Waist/H...

Brief summary: This pooled study, including five cross-sectional or intervention studies (n=24–823) and using publicly available data from genome-wide association studies (GWAS) to perform Mendelian randomization, investigated the influence of glucose, insulin, body fat, body mass index (BMI), food intake, and physical activity on serum soluble leptin receptor (sOb-R) levels. The authors showed that insulin and BMI were associated with decreased serum sOb-R level...