ESPE Yearbook of Paediatric Endocrinology

Brief summary: This study analyzed cross-sectional data on almost 5,000 adolescents from the Adolescent Brain Cognitive Development (ABCD) cohort data (https://abcdstudy.org/), including resting state functional MRI, structural MRI and neurocognitive task scores. Excess BMI in young adolescents was associated with profound aberrant topological alterations in maturating functional circuits, as well as with underdeveloped brain structures that may adversely impact cogni...

Brief summary: This randomized, controlled study in healthy-weight individuals examined the effect of a daily high-fat/high-sugar (HF/HS) intervention over 8 weeks on fat and sugar preference, alterations of brain response to food and sensory associative learning. It addressed the question, whether the association between obesity and altered brain function is pre-existing, is secondary to obesity or is attributed to western diet.Current models of obesity...

Brief summary: Roth et al. studied the relationship between obesity outcomes and meal-induced changes in neural activation to high- versus low-calorie food cues before and after 24-week family-based behavioral treatment (FBT) in n=28 children (9–11 years) with obesity and in n=17 children of healthy weight without intervention (9–11 years). Among children with obesity who underwent FBT, unfavorable changes were observed in peripheral hormon...