ISSN 1662-4009 (online)

Previous issue | Volume 21 | ESPEYB21

Yearbook of Paediatric Endocrinology 2024

ey0021.1-1 | New Mechanisms | ESPEYB21

1.1. SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability

Lettieri A. , Oleari R. , van den Munkhof M.H. , van Battum E.Y. , Verhagen M.G. , Tacconi C.

Brief Summary: This research identifies a role for SEMA6A in puberty onset by regulating median eminence vascular permeability.The authors elegantly use murine transgenics of Sema6a -/- combined with cell biology, biochemical assays and human genetics to identify a previously unknown role for Sema6a in regulating vascular permeability of endothelial cells within the median eminence (ME) to maintain neuroendocrine homeostasis. The role of SEMA6A ...

ey0021.1-2 | New Mechanisms | ESPEYB21

1.2. Kisspeptin signalling in astrocytes modulates the reproductive axis

Torres E. , Pellegrino G. , Granados-Rodriguez M. , Fuentes-Fayos A.C. , Velasco I. , Coutteau-Robles A.

Brief Summary: This study uses a combination of proteomics and murine transgenics to identify the role of Kisspeptin signalling in astrocytes and how it impacts the reproductive axis.Kisspeptin, a neuropeptide, is essential for regulating the hypothalamic-pituitary-gonadal (HPG) axis, which controls reproduction by acting on GnRH neurons. While most studies have focused on GnRH neurons as the primary mediators of kisspeptin signalling and function, this ...

ey0021.1-3 | New Mechanisms | ESPEYB21

1.3. Novel candidate regulators and developmental trajectory of pituitary thyrotropes

M. Cheung L.Y. , Menage L. , Rizzoti K. , Hamilton G. , Dumontet T. , Basham K.

Brief Summary:This study used single-cell RNA-seq and murine transgenic models combined with elegant cell lineage tracing to characterise the gene expression profiles and trajectories of pituitary thyrotropes. It identifies a novel population of pituitary thyrotropes that co-express Nr5a1 (Sf1) and Pouf1 (Pit1) and a novel developmental trajectory for a subpopulation of Nr5a1-derived thyrotropes.Classical studies on pituitary cell lineages and cell diffe...

ey0021.1-4 | New Mechanisms | ESPEYB21

1.4. SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context

Rizzoti K. , Chakravarty P. , Sheridan D. , Lovell-Badge R.

Brief Summary: This study investigated the functional diversity of SOX9-positive pituitary stem cells (PSCs) using sophisticated murine transgenics combined with single-cell mRNA-seq (sc-mRNAsq). It identifies that the ability of Sox9+ve PSCs to maintain progeny varies depending on their location and surrounding context.The authors elegantly show that the SOX9 transcription factor marks a population of stem cells in the pituitary gland. The authors FAC-s...