ESPE Yearbook of Paediatric Endocrinology

Brief Summary: Longitudinally collected samples from the Type 1 Diabetes Prediction and Prevention (DIPP) study were used to assess potential differences in immune responses in children at genetic risk of type 1 diabetes (T1D) who later progressed to clinical disease, stratified by autoantibody appearance (IAA-first, GADA-first, ≥2 autoantibodies (AAb)-first groups). Differences in the composition of peripheral blood monoclonal cells (PBMC) were found between the IAA-fir...