ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This review describes the heterogeneity in type 1 diabetes (T1D), the emerging concept of endotypes, and their impact on T1D prediction, prevention and treatment.Growing evidence supports the existence of heterogeneity in T1D genetic background, pathogenesis, clinical course, susceptibility to complications and response to emerging immunotherapy (1,2). This has led to the concept that T1D is not a single disease; instead there are distinct...