ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This genetic epidemiology study genotyped n=248 unrelated children aged 9-12 years, computed 4 weighted polygenic risk scores (PRS), and investigated the associations between (1) appetitive traits and BMI, (2) PRSs and BMI, and (3) PRSs and appetitive traits. Appetite traits were evaluated using an obesogenic appetite score, which was calculated by combining mean scores of the food approach and food avoidance domains from the Child Eating Behavior Questionnaire....

Brief Summary: This exome-wide association study conducted in the UK Biobank cohort (n=454 787) and in two non-European cohorts, the Mexican MCPS cohort (n=141 046) and the Pakistani PGR cohort (n=37 800), identified a association between rare protein-truncating variants (PTVs) in the APBA1 and the BSN genes and adult-onset obesity, suggesting two new genes as possible causes for monogenic obesity. Rare PTVs in BSN were also associated with Type 2 di...