ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This longitudinal observational study combined data from the SEARCH (T1D: N=564; T2D: N=149) and TODAY studies (T2D: N=495). Complications were higher in those with childhood onset T2D compared to T1D, with T2D showing 2.5 to 4 times higher rates of microvascular, macrovascular events despite similar diabetes duration. Risk factors for complications differed between T2D and T1D, with mean arterial pressure being a common predictor for both.<p class="abstext"...

Brief Summary: The authors performed exploratory analyses to identify distinct eGFR trajectories associated with risk of albuminuria in 377 adolescents with T2D. The findings underscore the importance of annual GFR assessments in young people with T2D.Comment: Diabetic kidney disease (DKD) is the primary microvascular complication in adolescents with T2D, and is a leading cause of morbidity and mortality. Albuminuria is the earliest clinical indicator of...

Brief Summary: This population-based cohort study estimated all-cause and cause-specific mortality in 108,061 individuals with newly diagnosed T2D, (16–50 years of age) compared to 829,946 individuals without T2D. Higher relative risks of mortality in younger individuals with vs. without T2D ranged from 4 to 11, depending on the cause of death.Comment: A decade ago, a Markov-like computer model simulated the life course of a hypothetical cohort of U...