ESPE Yearbook of Paediatric Endocrinology

Brief Summary: The authors propose a simplified definition of pediatric metabolic syndrome (MetS) for children aged 6-17 years. This uses static cut-offs, enabling easier and quicker assessment in clinical practice, and allowing comparison of MetS prevalence across different pediatric populations.Comment: There is no consensus on the definition of pediatric metabolic syndrome (MetS). Existing pediatric MetS definitions involve age-, sex- or height-specif...

Brief Summary: Artemisinins, compounds known for their antimalarial properties, suppress ovarian androgen synthesis by promoting degradation of cytochrome P450 11A1 (CYP11A1). Hence, they are a promising new approach for preventing and treating PCOS.Comment: Polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic anovulation, and insulin resistance, is one of the most common reproductive endocrinopathies, affecting ~8-18% of reproduc...

Brief Summary: This observational study assessed the association between metabolic syndrome (MetS) and its components with structural neuroimaging outcomes and cognitive domains in 37,395 dementia-free adults from the UK Biobank. MetS was associated with poorer brain health, characterized by reduced brain volume, increased vascular pathology, and diminished cognitive function.Comment: MetS is characterized by the cluster of central obesity, hypertension,...