Pregnancy and Youth Onset T2D

ey0021.12-8 | Pregnancy and Youth Onset T2D | ESPEYB21

12.8. Impact of youth onset type 2 diabetes during pregnancy on microvascular and cardiac outcomes

JB Tryggestad , KL Drews , L Mele , S Arslanian , SD Chernausek , EN Escaname , M Geffner , E Isganaitis , J Sprague , MM; TODAY Study Group. Kelsey

Brief Summary: This observational study showed that pregnancy increases the risk of hyperfiltration in women with youth-onset T2D, but not other micro or macrovascular complications.Comment: This study examined whether pregnancy exacerbates health outcomes in young women with T2D, particularly by testing for changes in the occurrence of microvascular and macrovascular complications. Previous findings showed that women in their fourth decade experience a ...

0 shares

ey0021.12-9 | Pregnancy and Youth Onset T2D | ESPEYB21

12.9. DNA methylation signatures of youth-onset type 2 diabetes and exposure to maternal diabetes

OE Salama , N Hizon , M Del Vecchio , K Kolsun , MA Fonseca , DTS Lin , O Urtatiz , JL MacIsaac , MS Kobor , EAC Sellers , VW Dolinsky , AB Dart , MJ Jones , BA Wicklow

Brief Summary: This cross-sectional analysis showed that DNA methylation (DNAm) patterns differ between youth-onset and adult-onset T2D. In utero exposure to maternal diabetes was linked to these distinct changes. These findings highlight unique molecular pathways disrupted by youth-onset T2D, and suggest potential intervention targets to prevent its health impacts.Comment: Growing evidence suggests that T2D in children and adolescents is essentially dif...

0 shares

ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2024

12. Type 2 Diabetes, Metabolic Syndrome and Lipids

12.8. Impact of youth onset type 2 diabetes during pregnancy on microvascular and cardiac outcomes

12.9. DNA methylation signatures of youth-onset type 2 diabetes and exposure to maternal diabetes

BiosciAbstracts