ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This commentary argues to refocus the WHO Model List of Essential Medicines on the needs of low and middle-income countries, reiterating the original goals of the process to promote equitable access to medicine and improve health globally.The World Health Organization (WHO) Model List of Essential Medicines, first published in 1977, is designed to promote equitable access to essential medicines that address the priority health needs of pop...

Brief Summary: This systematic review investigated the physical residual effects of treatment on pediatric cancer survivors in low- and middle-income countries (LMICs), a topic with substantial information voids. Selection bias, limited sample sizes, and wide differences in the definition of long-term treatment effects were identified and these limited the ability to perform meta-analyses.In high-income countries (HICs), the 5-year survival rates followi...

Brief Summary: The authors describe the development and utility of an international collaborative database in congenital adrenal hyperplasia (CAH). I-CAH serves as a tool for benchmarking clinical care and supporting research and development of novel therapies.Rare disease registries can form the basis of best practice guidelines and allow for monitoring of new drugs and therapeutic interventions. The I-CAH Registry was developed as an international plat...

Brief Summary: Countries differ in their approaches to newborn screening (NBS) for congenital adrenal hyperplasia (CAH), a group of genetic disorders affecting adrenal steroidogenesis. This survey describes the protocols, approaches, and outcomes of CAH screening across different countries.Members of the International Society for Neonatal Screening were invited to complete a questionnaire in 2021. Members representing 23 screening programs from Europe, S...

Brief Summary: This review describes the widespread global issue of childhood rickets, focusing on how disparities in health, nutrition, and environmental factors contribute to its prevalence.Nutritional rickets is primarily caused by deficiencies in vitamin D or calcium, often due to inadequate nutrition or lack of sunlight exposure. This leads to impaired bone development in children, with potential lifelong consequences. Rickets has historically been ...

Brief Summary: This prevalence study examined global, regional and national trends in iodine deficiency among adolescents and young adults, based on data from the Global Burden of Disease (GBD) 2019 database.Iodine deficiency is a significant public health concern as it can result in hypothyroidism, goiter, and alterations in growth and development. While universal salt iodination has had a significant impact, there is a need for better estimates of the ...