ESPE Yearbook of Paediatric Endocrinology

Brief Summary:This study shows that brain-derived cellular communication network factor 3 (CCN3) is a potent osteoanabolic hormone to enhance bone formation in lactating female mice. CCN3 is produced by KISS1 neurons in the brain, and operates through a unique signaling pathway that interacts with bone-forming osteoblasts leading to increased bone formation.During lactation, the increased calcium demand for milk production leads to considerable bone loss...

Brief Summary:This basic science study, using mice, cell models, and organoids, shows that the cAMP-binding protein EPAC1 is a central regulator of adaptive brown adipose tissue (BAT). EPAC1 specifically increases the number of thermogenic fat cells (brown and beige adipocytes), by promoting the differentiation and growth of brown adipocytes and the development of beige adipocytes through signaling pathways that enhance lipid metabolism and thermogenesis.<p class="abstext"...