ESPE Yearbook of Paediatric Endocrinology

In Brief: The population-based Stockholm-Gotland Perinatal Cohort study analysed electronic medical records on 15 760 pregnancies with obesity, followed up for a median of 7.9 years. In pregnancies with class 1 or 2 obesity, low gestational weight gain (GWG, mean 0 kg at 40 weeks) did not increase risk of the adverse composite outcome (class 1: adjusted RR 0.97 [95% CI 0.89–1.06]; class 2: 0.96 [0.86–1.08]). In pregnancies with class 3 obesity, low GWG (mean 0 kg at ...

In Brief: The authors investigated intraperson variability in fasting glucose (FG) levels using continuous glucose monitoring (CGM) devices in 8315 nondiabetic adults aged 40–70 years. Day-to-day intraperson standard deviation of FG was 7.52 mg/dl (0.42 mol/l). This high variability has a large estimated impact on the classification of glycemic status (normal FG, prediabetes or diabetes). Of 5328 adults classified as having normal FG based on their Day 1 measurement, 40% ...

In Brief The authors report a genome-wide association study (GWAS) on Type 2 diabetes (T2D), including data from 2 535 601 individuals (39.7% non-European ancestry), including 428 452 with T2D. They identify 1,289 independent GWAS signals (at P < 5×10−8), of which 145 loci are novel. These genetic signals cluster into 8 groups, with differing cardiometabolic trait associations and differing cell-specific profiles of gene activation (open chro...

In Brief: The authors harness large-scale genetic and DNA methylation datasets in an epigenome-wide Mendelian randomization approach, to identify CpG sites that appear to be causally related to aging-related traits. These sites are collated to produce 2 epigenetic clocks: DamAge has adverse impacts on age-related outcomes, including mortality. AdaptAge appears to confer beneficial adaptations.Steve Horvath and others originally described various epigenet...