ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This study compared the histology and growth phenotypes, epigenotypes and gene expression profiles of mouse embryos, embryonic livers, and placental tissue at differing gestational ages after exposure to IVF. They followed the growth and metabolic profiles (glucose, insulin, triglycerides, total cholesterol, HDL, LDL/VLDL) of offspring to age 12 weeks. Groups analysed by sex included those conceived naturally, by IVF, by IVF with TEBx (trophectoderm biopsy) and ...

Brief Summary: This population-based national register study searched for imprinting-related disorders in all liveborn singletons in Sweden (N=2,084,127) born between 1997 and 2017 with follow-up to Dec 2018. They identified 1,044 children with Beckwith-Wiedemann Syndrome (BWS), Prader-Willi Syndrome (PWS)/Silver-Russell Syndrome (SRS), or central precocious puberty (CPP), of whom 52 were conceived using ART therapy. The risk of being diagnosed with any of these disorders was ...