ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This study examined the regulation of thyroid hormone (TH) levels by thyrotropin-releasing hormone (TRH) neurons located in the paraventricular nucleus (PVN) of the hypothalamus in fed and fasted mice. It focused on the role of agouti-related peptide (AgRP)/neuropeptide Y (NPY) neurons in the arcuate nucleus.Using chemogenetic activation in mice, the authors demonstrated that TRH neurons play a direct role in regulating the hypothalamic-pi...

Brief Summary: This study examined the pulsatile secretion of TSH and its regulatory role in thyroid hormone (TH) synthesis in mice. Using a novel ultra-sensitive ELISA for mouse TSH, it shows that TSH pulsatility plays a critical role in regulating thyroid function.In addition to mapping the normal TSH secretion pattern in healthy mice, and the secretion pattern in a mouse model of disease (mouse made hypothyroid by an iodine-deficient diet enriched wit...